A WHO committee visited China and found evidence that a pandemic had begun as a result of a zoonotic viral infection. This means a spillover from animals to humans.
SARS-CoV-2 has caused the largest pandemic in the last 100 years. Understanding its origin is important to know what happened in late 2019 and to prepare for the next pandemic virus.
These studies require time, planning and cooperation. They must be driven by science, not politics or attitude. Investigating the origin of SARS-CoV-2 has already taken too long. More than 20 months have passed since the first case was found in Wuhan, China in December 2019.
This week, US President Joe Biden was briefed by US intelligence on an investigation into the origin of the causative virus. COVID-19 (New Coronavirus Infection) , according to media.. A portion of the research report will be published within a few days.
Early report from The New York Times Suggest a survey It does not conclude whether the spread of the virus was due to a laboratory leak or a spontaneous animal-to-human spillover effect.
The possibility of lab leaks is a series of investigations (if scientific evidence is revealed), but distracts us from telling us that current evidence should direct most of our energy. It is not. Over time, it becomes impossible for experts to identify the biological origin of the virus.
I was one of the experts who visited Wuhan Earlier this year As part of a World Health Organization study on the origin of SARS-CoV-2. Evidence was found to indicate that a pandemic began as a result of a zoonotic viral infection. This means a spillover effect from animals to humans.
Today, I and the other independent authors of the WHO report written I plead for this work to be accelerated. The important time to deal with the following six priorities is running out.
- Further traceback studies based on reports of early illness
- SARS-CoV-2 specific antibody survey in early areas COVID-19 (New Coronavirus Infection) Case.This is important given that many countries, including Italy, France, Spain and the United Kingdom, have not reported early conclusive evidence. COVID-19 (New Coronavirus Infection) detection
- Tracebacks and community surveys of people involved in wildlife farms that supplied animals to the Wuhan market
- A study of potential animal host risks. This is either the primary host (such as a bat), or the secondary host or amplifier.
- Detailed risk factor analysis of early case pockets, wherever they occur
- Follow-up of new leads you can trust.
Fight against time
The biological feasibility of some of these studies is time-dependent. SARS-CoV-2 antibodies appear about a week after someone is infected and recovers from the virus or is vaccinated.
However, antibodies have been found to decrease over time. As a result, samples currently collected from people infected before or around December 2019 can be difficult to determine accurately.
It is also problematic to use antibody studies to distinguish vaccinations, spontaneous infections, and even secondary infections (especially if the first infection occurs in 2019) in the general population.
For example, after spontaneous infection, various SARS-CoV-2 specific antibodies, such as peplomer and nucleoprotein, can be detected for different lengths of time, different concentrations and the ability to neutralize the virus.
However, depending on the vaccine used, only antibodies against the SARS-CoV-2 peplomer may be detected. These also decrease over time.
There is also a need for international consensus on the experimental methods used to detect SARS-CoV-2 specific antibodies. Inconsistencies in testing methods have led to discussions about data quality from many locations.
It takes time to reach consensus on experimental techniques for serological and viral genome research, access and sharing of samples, including addressing consent and privacy concerns. It also takes time to secure funds. Therefore, time is not a wasteful resource.
Distance from potential sources
In addition, many wildlife farms in Wuhan were generally closed in unidentified ways after the first outbreak.And find evidence of early humans or animals coronavirus As animals and humans disperse, the spillover becomes more difficult.
Fortunately, some research can now be done. This includes reviews of early case studies and studies of blood donors in Wuhan and other cities in China (and elsewhere where there was early detection of the viral genome).
While it is important to investigate the progress or results of such studies by local and international experts, the mechanism for such scientific inter-investigation has not yet been put in place.
New evidence has been presented since the March report.These treatises and WHO report data have been reviewed by scientists Independent from WHO Group.. They came to a conclusion similar to the WHO report and identified the following:
- No host reservoir for SARS-CoV-2 was found
- Major species in China (or elsewhere) may not have been tested
- There is substantial scientific evidence to support the origin of zoonotic diseases.
Wobble back and forth
The possibility of a laboratory accident cannot be completely ruled out, but it is unlikely given the repeated human-animal contact that occurs routinely in wildlife trade.
Nevertheless, the “Laborique” hypothesis continues to generate media interest, in addition to the available evidence. These more political debates further delay the cooperation and agreement needed to advance Phase 2 research in the WHO Report.
The World Health Organization has called for a new committee to oversee future origin studies. This is commendable, but there is a risk of further delaying the planning needed to study the SARS-CoV-2 origin already outlined.
Dominic Dwyer, Westmead Hospital and University of Sydney, University of Sydney, New South Wales Department of Health Pathology, Department of Public Health Pathology
Soon, it will be too late to know where and how the COVID-19 virus occurred in China-Health News, Firstpost
Source link Soon, it will be too late to know where and how the COVID-19 virus occurred in China-Health News, Firstpost