COVID Delta variant affecting unvaccinated NC children


Pediatric cases on the rise as vaccine trials for children continue. Children under the age of 12 remain unvaccinated as COVID vaccines are not yet approved for them.

By Anna Deen

Carolina Public Press

Younger, unvaccinated populations are enduring the effects of the rapidly spreading Delta variant of COVID-19, with children representing a higher percentage of positive cases than in the past, Atrium Health officials said in a press conference Tuesday.

As of July 15, children represent 12.7 percent of cumulated positive cases in the state, up .1 percent since the start of the month, according to data from the American Academy of Pediatrics. However, over the first two weeks of July, children have made up 15.3 percent of all new cases.

National data shows a similar trend, with pediatric cases representing 43,033 of new cases over the same time period.

The Delta variant, which is more contagious and severe than other strains, is the dominant version of the coronavirus, accounting for about 83 percent of new cases nationwide, Dr. Rochelle Walensky, director of the Centers for Disease Control and Prevention, said during a Senate committee hearing Tuesday.

Children are especially vulnerable to some complications of infection including MIS-C, or Multisystem inflammatory syndrome, a rare but potentially serious condition requiring hospitalization.

The rate of hospitalizations for the Delta variant is two times higher than that of earlier variants, with nearly 99 percent of admitted hospital patients unvaccinated, Dr. Katie Passaretti, a medical director of infection prevention at Atrium Health, said. Providers are also starting to see an increase, from what had been extremely low levels, in ICU-level patients and patients on ventilators.

But the rising infection rate has not resulted in rising hospitalization rates among children in the Atrium Health service area.

“We’re actually not seeing an increase in hospitalization in our children, and hopefully that will continue to stay that way,” Dr. Amina Ahmed, a pediatric infectious disease expert and epidemiologist at Levine Children’s Hospital, an Atrium Health facility, said.

Nationally, it’s a slightly different story, with hospitalizations for 12-to-17 year olds increasing, Dr. Ahmed said.

Low vaccine rates for youth

One reason for the shift since the beginning of the year is because younger populations are less likely to be vaccinated.

In North Carolina, about one-quarter of teenagers between the ages of 12 and 17 have received both shots. By comparison, 83 percent of adults 65 and older are fully vaccinated, according to North Carolina Department of Health and Human Services data.

“With only 24 percent of North Carolinians ages of 12 and 17 fully vaccinated, and because anyone under the age of 12 cannot be vaccinated yet, we still have a long way to go,” NC DHHS Secretary Mandy Cohen said at a press conference Wednesday.

The Department released a “StrongSchoolsNC” toolkit encouraging districts to adopt mask policies for unvaccinated students.

Governor Roy Cooper declined to detail specific enforcement measures if a district opts not to enforce a mask policy. “We all know what to do,” he said. “We need to all pull together and make sure we try to get it done.”

Pediatric vaccine trials underway

The Pfizer-BioNTech is the only vaccine currently approved for children ages 12 and up. Moderna is likely on track to offer a second option for teenagers, having filed for emergency use authorization from the U.S. Food and Drug Administration in June.

For children under 12, vaccines may be available early to mid winter, an FDA official said earlier this month.

Pfizer’s pediatric clinical trials are currently underway, involving up to 4,500 participants ages six months to 11 years across 90 clinical sites in the U.S., Poland, Spain and Finland.

Pfizer, which is testing lower doses for children, anticipates having results for five to 11 year olds — who are receiving 10-microgram doses as opposed to the 3-microgram doses that children under five are receiving — by September. By contrast, those older than 12 received 30-microgram doses.

Results for two-to-five year olds should be available soon after, and results for those under two by October or November.

In March, Moderna announced plans to run pediatric clinical trials, scheduled to begin August 7, with roughly 6,750 participants in the same age groups across the U.S. and Canada.

The companies use trial results to submit to the FDA for Emergency Use Authorization.

Children, especially infants and toddlers, require separate vaccine trials because they may have not yet built immune systems strong enough to respond to some vaccines, making their responses stronger than those of adults.

“One key goal of the COVID-19 vaccine clinical trials in children will be to determine the optimal dosage for each age group,” Judy Martin, professor of pediatrics at the University of Pittsburgh, wrote in The Conversation.

State health officials encourage unvaccinated adolescents eligible for shots now to get them.

NC DHHS launched an incentive program for youth, Summer Cash 4 College, where participants under 18 who receive their full vaccination are eligible to win scholarship funds through August 4. Some organizations are hosting vaccine walk-in events that target young people.

Free COVID-19 vaccines are available to everyone over the age of 12, and can be scheduled through the Find My Vaccine Provider online tool.

Complications due to vaccinations are extremely rare, in the order of a few per million doses given, Dr. Passaretti of Atrium Health said. “The risk of vaccination is so far below the risk of getting COVID infection.”

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